Nrf2 Synergizer®

Uses advanced technology to support the body's natural ability to repair and rejuvenate its own cells.

Protandim Nrf2 Synergizer

Vegan Vegetarian




Free from artificial colors, flavors, and sweeteners

Protandim® Nrf2 Synergizer®

Protandim® Nrf2 Synergizer®, is a breakthrough nutritional supplement that boosts your body's own ability to produce powerful antioxidants. It has been clinically shown to reduce the oxidative stress associated with aging, leading to improvements in energy, vitality and overall health.*


  • Reduces oxidative stress by 40% in just 30 days*
  • Helps the body detoxify genes, keeping the master blueprint of the cell’s function intact*
  • Significantly reduces cellular stress through Nrf2 activation*
  • Produces enzymes capable of neutralizing more than 1,000,000 free radicals*
  • Helps to regulate survival genes*
  • Supports the body's natural ability to repair and rejuvenate its own cells*

How Much Does The LifeVantage Protandim® Nrf2 Synergizer® Cost?

Protandim Nrf2 Synergizer is sold in a container with a content of 30 caplets. You can buy it depending on the area you are located. Check out our LifeVantage overview.
The pricing of the LifeVantage Protandim Nrf2 Synergizer depends on the country, and the buying option. In the USA, you can buy it with a One-Time Order at the List Price of $59,99. Or, you can buy it with Subscribe & Save, cancel anytime, shipping discounts, and exclusive offers, for the price of $49,.99. You can benefit from buying the LifeVantage Dual Synergizer, or Tri-Synergizer.

Reduce the impact of Stress, Pollution and Unhealthy Habbits. Repair and rejuvenate your own cells with Protandim® Nrf2 Synergizer®.

What's Inside the Little Yellow Activator?

All about LifeVantage Protandim Nrf2 Synergizer ingredients.

Turmeric Root Nrf2 Synergizer ingredient


Nrf2 Synergizer® - Turmeric ingredient,  is formulated to help protect against cellular stress. Turmeric has been used for 4,000 years in Ayurvedic and Chinese medicine shown to help fight cellular stress, maintain joint health, and aid digestion.*

Ashwagandha Nrf2 Synergizer ingredient


Nrf2 Synergizer® - Ashwagandha ingredient, is a “super adaptogen” that helps with mental and physical fatigue and stress. Ashwagandha has been used for centuries in the Ayurvedic medicing for its multiple health benefits, including support for memory enhancement and restful sleep.*

Green Tea Extract Nrf2 Synergizer ingredient

Green Tea

Nrf2 Synergizer® - Green Tea ingredient, contains high concentration of powerful antioxidants and known to support healthy mental processes and cardiovascular health.*

Milk Thistle Nrf2 Synergizer ingredient

Milk Thistle

Nrf2 Synergizer® - Milk Thistle ingredient, is a potent formulation that is more bioavailable than milk thistle alone. It supports your body's own detoxification process. It also supports healthy liver, kidney, and gallbladder function.*

Bacopa Nrf2 Synergizer ingredient


Nrf2 Synergizer® - Bacopa ingredient, known to promote cognitive abilities, concentration, and alertness, and studies suggest it provides strong cellular defense.*

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Activate Healthy Aging

Protandim® Nrf2 Synergizer® is the only supplement on the market that has been scientifically proven to reduce oxidative stress by 40% in just 30 days, the cellular damage caused by free radicals. Oxidative stress is a key contributor to the signs of aging.

Repair and rejuvenate

Protandim® Nrf2 Synergizer® is a scientifically-backed supplement that has been shown to support the body's natural ability to repair and rejuvenate. By activating Nrf2, Protandim® boosts antioxidant production and helps fight oxidative stress.

Protandim® Nrf2 Synergizer® Testimonials

NRF2 Synergizer™ Usage

Directions: Take one caplet daily with food.
Warnings: If you are pregnant, nursing, or on immunosuppressive therapy, please consult with your physician before taking Protandim.
Note: 100% Vegetarian. Gluten-free and dairy-free.
Protandim Nrf2 Synergizer-NRF2 Infographic 2048x1024

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What Is The Oxidative Stress Theory of Aging? Protandim NRF2

Nrf2 Synergizer® Label Info

Serving Size
1 Caplet
Servings Per Container
Per Serving Amount DV% **
Calcium (as dicalcium phosphate and calcium carbonate) 77mg 8%
Proprietary Blend 675mg †
Milk Thistle Extract (Silybum Marianum) Seed
Bacopa Extract (Bacopa Monnieri) Whole Herb
Ashwagandha Extract (Withania Somnifera) Root
Green Tea Extract (Camellia Sinensis) Leaf
Turmeric Extract (Curcuma Longa) Rhizome
Other Ingredients
Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides.

** % Daily value based on a 2,000 calorie diet.

*** Compared to the free radical scavenging capacity of 2g of Vitamin C.

† Daily value not established.

Nrf2 Synergizer® FAQ

Protandim Nrf2 Synergizer is the only supplement proven in a peer-reviewed, human clinical study to reduce cellular stress in humans by an average of 40 percent in 30 days. Protandim Nrf2 Synergizer is patent protected and is the subject of 20 peerreviewed clinical studies. Protandim Nrf2 Synergizer works to support the body’s own protective measures by turning on its internal antioxidant defense system, regulated by the protein Nrf2. When activated, Nrf2 triggers cells to produce naturally occurring antioxidant enzymes as well as housekeeping “cleanup” proteins which work together to deliver balanced protection against cellular stress.

  • Withania somnifera (Ashwagandha) root extract
    (sourced from India)
  • Camellia sinensis (Green Tea) leaf extract
    (sourced from China)
  • Silybum marianum (Milk Thistle) seed extract
    (sourced from China)
  • Bacopa monnieri (Bacopa) whole plant extract
    (sourced from India)
  • Curcuma longa (Turmeric) root extract (sourced
    from India)

Dicalcium Phosphate and Calcium Carbonate (listed as “Calcium” in the Supplement Panel), Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides. The “Other Ingredients” in Protandim Nrf2 Synergizer serve as binding and processing aids during the production of the tablet.

No, they are not certified organic; however, at LifeVantage, we perform pesticide, herbicide and heavy metal testing on every lot of raw material to assure we have only safe, high quality products

Yes, the quality control measures implemented by LifeVantage go beyond industry standard. LifeVantage rigorously tests every lot of active raw material for identity, potency, microbial contamination, pesticides and heavy metals. Unlike most dietary supplement companies, we also physically audit all of our active raw material suppliers. We perform exhaustive testing to verify that all materials meet or exceed quality specifications.

No, the individual ingredients in Protandim Nrf2 Synergizer aren’t as effective in activating the Nrf2 pathway as LifeVantage’s proprietary and patented botanical blend. Our patents and previous studies of Protandim Nrf2 Synergizer have shown a very clear and potent synergy whereby the 5-ingredient blend is significantly more effective than any of the individual ingredients in 1) inducing Nrf2, 2) triggering the production of internal antioxidant enzymes and 3) stimulating the expression of a variety of cellular survival genes.

The raw ingredients are verified, carefully weighed out, blended and pressed into tablet form following strict Good Manufacturing Practices (GMP) guidelines. Every lot of finished Protandim Nrf2 Synergizer is tested for compliance to approved specifications in addition to receiving a final quality inspection following dietary supplement regulations. Every lot must, again, meet or exceed established finished product specifications before it can be released by LifeVantage Quality Assurance.

All LifeVantage facilities where Protandim Nrf2 Synergizer is manufactured are required to maintain a strict allergen program to protect against any potential cross contamination of allergens. These facilities are frequently audited to ensure that the processes and protocols are being strictly adhered to in order to ensure the safety of the product. 

No, there are no dyes or food colorings in Protandim Nrf2 Synergizer. One of the active ingredients in Protandim Nrf2 Synergizer, Curcuma longa (Turmeric) is intensely yellow, adding to the yellow coloring of the tablet.

Protandim Nrf2 Synergizer is 100% vegetarian and free from gluten, wheat, dairy, gelatin and yeast.

No, Silybum marianum (Milk Thistle) is a plant used in traditional Chinese medicine. While “milk” is in the name, this ingredient does not contain any dairy.

Yes, the FDA regulates both finished dietary supplement products and dietary ingredients. Dietary supplements are regulated under a different set of regulations than those covering conventional foods and drug products. Manufacturers and distributors of dietary supplements and dietary ingredients are prohibited from marketing products that are adulterated or misbranded. Firms are responsible for evaluating the safety and labeling of their products in order to comply with the Dietary Supplement Health and Education Act (DSHEA) and FDA regulations. The FDA closely monitors the marketplace for illegal products (products that may be unsafe or make misleading claims) in a variety of ways, including inspections of dietary supplement manufacturers and distributors, dietary supplement websites, consumer complaints, and occasional laboratory analyses of products.

Although dietary supplement manufacturers must register their facilities with the FDA, they are not required to get FDA approval before producing or selling dietary supplements. Manufacturers and distributors must ensure all claims and information on the product label and any other labeling are truthful and not misleading. Under FDA regulations, all domestic and foreign companies that manufacture, package, label or hold dietary supplements, including those involved with testing, quality control, and dietary supplement distribution in the U.S., must comply with current Good Manufacturing Practices (cGMPs) for dietary supplements.

Yes, we meet or exceed cGMPs for Dietary Supplements. LifeVantage establishes the safety and purity of all its ingredients through independent laboratory testing, auditing and third party certifications. We have one of the most comprehensive quality systems in the industry, and many other companies now request the same quality standards that LifeVantage requires of our manufacturers and suppliers.

Yes, Protandim Nrf2 Synergizer is certified by NSF International. Certification by NSF means that an independent organization has reviewed the manufacturing process of a product and determined that the final product complies with specific standards for safety, quality or performance. NSF certification is recognized by regulatory agencies at the local, state, federal and international level, and NSF periodically conducts audits and product testing to verify that the product continues to comply with the standard.

Yes! Protandim Nrf2 Synergizer is not a controlled substance, nor does it contain any banned or controlled substances. The BSCG symbol on the Protandim Nrf2 Synergizer label assures all consumers and especially professional athletes that every lot of Protandim Nrf2 Synergizer has been analyzed and certified by the Banned Substances Control Group (BSCG) to be free of all substances banned by the World Anti-Doping Agency

Many people mistakenly believe their antioxidant needs are fulfilled by eating blueberries, drinking expensive “miracle juices” and applying antioxidant facial creams. What they don’t realize is that their daily antioxidant needs cannot be fulfilled by consuming any amount of blueberries, dark chocolate or red wine. Effective antioxidant protection absolutely requires adequate production of the body’s own antioxidant enzymes. Protandim Nrf2 Synergizer contains a unique, patented blend of ingredients that have been proven to stimulate the production of antioxidant enzymes and protect against cellular stress.

Instead of providing the body with additional dietary antioxidants, Protandim Nrf2 Synergizer supports your body from within by turning on its own antioxidant defense system. By upregulating the production of antioxidant enzymes and other protective proteins, Protandim Nrf2 Synergizer helps to reduce free radical damage and prepare cells for exposure to future stressors. Additionally, each antioxidant enzyme can react with and deactivate millions of free radicals every second. This makes them exponentially more effective than dietary antioxidants, which can only scavenge free radicals on a “one-to-one” basis. This is why Protandim Nrf2 Synergizer is different than any other dietary supplement on the market today

Some of the active ingredients in Protandim Nrf2 Synergizer are fat soluble, so taking Protandim Nrf2 Synergizer with a meal containing some fat allows the ingredients to be absorbed more efficiently (but it’s not absolutely necessary).

Protandim Nrf2 Synergizer contains 1.8 mg of caffeine per tablet. (By comparison, coffee may contain up to 150 mg and “caffeine free” coffee may contain between 4-7 mg.)

The shelf life for Protandim Nrf2 Synergizer is 3 years from date of manufacture.

No, there is no known mechanism whereby Protandim Nrf2 Synergizer loses effectiveness over time. The formula has not been changed and bioactivity is monitored to maintain consistent potency with regard to the activation of the Nrf2 transcription factor (the mechanism by which Protandim Nrf2 Synergizer works).

As with any supplement, particularly if you have a medical condition, are taking medication or other supplements, you should speak with your healthcare provider before taking Protandim Nrf2 Synergizer. If you experience nausea, vomiting, diarrhea or any other difficulties after taking Protandim Nrf2 Synergizer, discontinue use and consult your healthcare provider.

Some Western diets are lacking in certain nutritional elements, so multivitamin supplementation may be beneficial for some people.

We do not expect there to be any side effects for the typical Protandim Nrf2 Synergizer consumer. However, some individuals may have natural allergic responses or sensitivities to one or more of the ingredients, just as some people are allergic to pollen or some nuts. Allergic responses to Protandim Nrf2 Synergizer generally appear as gastrointestinal disturbances (i.e., stomach ache, diarrhea, vomiting) or sometimes as a headache or rash on the hands or feet. The symptoms typically disappear if the allergen is discontinued. If you are experiencing any adverse reaction, discontinue use of the product and call (866) 460-7241.

Researchers and scientists agree that aging is the result of cellular deterioration caused by free radicals. It is impossible to avoid free radicals because the food you eat and the air you breathe, as well as stress or even vigorous exercise, can stimulate cells to produce destructive free radicals in staggering numbers. The human body fights free radicals by producing its own antioxidant enzymes, but as we grow older our bodies produce more free radicals and fewer of these antioxidant enzymes to fight the battle of aging. That’s where Protandim Nrf2 Synergizer plays a critical role by boosting the body’s production of antioxidant enzymes at the cellular level with enough neutralizing capacity to
reduce age-related increase in free radical damage.

Protandim Nrf2 Synergizer’s results stem from its ability to activate the transcription factor known as Nrf2. Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA. Protandim Nrf2 Synergizer contains 5 ingredients in a patented combination that are known as Nrf2 activators. When Nrf2 is activated, it enters the nucleus and turns on several hundred genes, known collectively as “survival genes.” These genes enable cells to survive in the face of several different kinds of stress, especially oxidative stress, which occurs when free radicals and other oxidants overwhelm the body’s natural antioxidant enzymes. As a Nrf2 activator, Protandim Nrf2 Synergizer helps keep the body safe from free radicals and oxidants by activating these survival genes.

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